Gaolin Liang, Ph.D.
EDUCATION AND RESEARCH EXPERIENCE
1989-1993, Nanjing University, B.S.
2000-2002, Zhengzhou University, M.S. Ph.D.
2002-2005, Fudan University, Ph.D.
2005-2008, Hong Kong University of Science and Technology, Postdoc
2008-2010, Stanford University, Postdoc
2010-present, Professor, School of Chemical Physics, University of Science and Technology of China
RESEARCH INTERESTS
The research in our group mainly focus on: 1, Nanochemistry. We actively explore new methodologies (reactions) for synthesizing nanomaterials, including dendrimers, supermolecular hydrogelators, and inorganic nanoparticles for bioengineering applications. 2, Molecular and Cellular Imaging. We develop novel molecular probes for imaging or manipulating targeted biomolecules in normal and diseased states, usually for cancer early detection. 3, Imaging modality. We combine different imaging modalities for disease dignosis, therapy evaluation, et al.
REPRESENTATIVE PUBLICATIONS
1. Jiali Tan,* Mei Zhang, Zijuan Hai, Chengfan Wu, Jiong Lin, Wen Kuang, Hang Tang, Yulei Huang, Xiaodan Chen, and Gaolin Liang*. Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano 2019, 13(5), 5616-5622
2. Zijuan Hai, Yanhan Ni, Dilizhatai Saimi, Hongyi Yang, Haiyang Tong, Kai Zhong,* and Gaolin Liang*. γ-Glutamyltranspeptidase-Triggered Intracellular Gadolinium Nanoparticle Formation Enhances the T2-Weighted MR Contrast of Tumor. Nano Lett. 2019, 19(4), 2428-2433
3. Peiyao Chen,# Yinchu Ma,# Zhen Zheng,# Chengfan Wu, Yucai Wang,* and Gaolin Liang*. Facile syntheses of conjugated polymers for photothermal tumour therapy. Nat. Commun. 2019, 2019, 10, 1192
4. Chengfan Wu, Rui Zhang, Wei Du, Liang Cheng,* and Gaolin Liang*. Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for the Enhanced Photoacoustic Imaging of Tumors. Nano Lett. 2018, 18(12), 7749-7754
5. Wei Tang, Zhibin Zhao, Yuanyuan Chong, Chengfan Wu, Qingzhi Liu, Jingbo Yang, Rongbin Zhou, Zhe-Xiong Lian,* and Gaolin Liang*. Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect. ACS Nano 2018, 12(10), 9966-9973
6. Jindao Wu,* Zhen Zheng, Yuanyuan Chong, Xiangcheng Li, Liyong Pu, Qiyun Tang, Liu Yang, Xuehao Wang,* Fuqiang Wang,*, and Gaolin Liang*. Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection. Adv. Mater. 2018, 30(45), 1805018
7. Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng*, Wei Jiang*, and Rongbin Zhou*. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat. Commun. 2018, 9, 2550
8. Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang,* and Rongbin Zhou*. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol. Med. 2018, 10: e8689