Wei Xiong, PhD
EDUCATION AND RESEARCH EXPERIENCE
03/2013- present Professor, University of Science and Technology of China
10/2011-03/2013 Research Fellow, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
10/2006-10/2011 Postdoctoral Fellow, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
09/2001-07/2006 Ph.D., School of Life Sciences, Peking University
09/1997-07/2001 B.S., School of Life Sciences, Peking University
RESEARCH INTERESTS
1. Developing new neurochemical technologies such as single-cell mass spectrometry, single-organelle mass spectrometry, mass spectrometry imaging.
2. Studying the changes of small molecule metabolites in the neurologic disease such as Alzheimer’s disease and Parkinson’s disease using single cell mass spectrometry and brain mass spectrometry imaging.
3. Understanding the neuronal circuit mechanism of sensory (especially pain) processing and its related neurological disorders, such as chronic inflammatory pain and allodynia and hyperalgesia in neuropathic pain. Developing new therapeutic medicine and treatment to relieve chronic pain.
REPRESENTATIVE PUBLICATIONS
1. Wang Xiaoqun ; Hou Yiwen; Hou Zhuanghao; Xiong Wei*; Huang Guangming*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization, Analytical Chemistry, 91(4): 2719~2726 (2019)
2. Chengyuan Liu, Keke Qi, Lei Yao, Ying Xiong, Xuan Zhang , Jianye Zang, Changlin Tian, Minggao Xu, Jiuzhong Yang , Zhenkun Lin , Yongmei Lv, Wei Xiong*, Yang Pan*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Analytical Chemistry, 91(10): 6616-6623 (2019)
3. Hongying Zhu#; Ning Wang#; Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li; Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang*;Wei Xiong*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain.Cell,173, 1716–1727 (2018)
4. Jieping Lu#; Sijia Fan#; Guichang Zou; Yiwen Hou; Tao Pan; Weiwei Guo; Lei Yao; Feng Du; GE Homanics; Dan Liu; Li Zhang;Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology, 133: 224~232 (2018)
5. Hongying Zhu#, Guichang Zou#, Ning Wang#, Meihui Zhuang,Wei Xiong* & Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. PNAS, 114: 2586~2591 (2017)
6. Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-LinZhao, Hong Chen, De-Pei Li, Gregg E. Homanics, John Peever, Kenner C. Rice,Ling-gang Wu, Hui-Lin Pan & Li Zhang. Presynaptic glycine receptors as apotential therapeutic target for hyperekplexia disease. Nature Neuroscience,17: 232-239 (2014). Highlight: Kingwell, K.Neurological disorders: Presynapticglycine receptors become a startling target.Nature reviews Drug discovery,doi: 10.1038/nrd4265 (2014).
7. Zhifeng Zhou, Camilla Karlsson, Tiebing Liang, WeiXiong, Mitsuru Kimura, Jenica D. Tapocik, Qiaoping Yuan, Estelle Barbier,Austin Feng, Meghan Flanigan, Eric Augier, Mary-Anne Enoch, Colin A.Hodgkinson, Pei-Hong Shen, David M. Lovinger, Howard J. Edenberg, MarkusHeilig, and David Goldman. Loss of metabotropic glutamate receptor 2 escalatesalcohol consumption. Proceedings of the National Academy of theSciences of the United States of America, 110(42):16963-8 (2013)
8. Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-RuiChen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang.Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycinereceptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
9. Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. ACommon Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation ofGlycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
10. Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski,Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptorscontributes to cannabis-induced analgesia. Nature Chemical Biology,7:296-303(2011). Also see NEWS AND VIEWS: Receptors: Cannabis medicine without ahigh. MacDonald J Christie & Christopher E Vaughan. Nature Chemical Biology, 7:249-250 (2011). Research Highlight: Nature Reviews Neuroscience 12:306 (2011). Commented and rated as ‘Must Read” by Faculty of 1000 (2011)
11. Wei Xiong*, Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience,184: 28-37 (2011)
Website：http://biox.ustc.edu.cn/szdw/zzbqnqrjh/201402/t20140224_190321.html
E-mail: wxiong@ustc.edu.cn
Phone：0551-63601736