Qiang Liu, PhD
EDUCATION AND RESEARCH EXPERIENCE
2012-present Professor, University of Science & Technology of China
2011-2012 Research Associate, Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania
School of Medicine
2005-2010 Postdoc Fellow, Department of Pediatrics Department of Cell Biology and physiology, Washington University
School of Medicine
2000-2005 Ph.D, Institute of Biophysics, Chinese Academy of Sciences
1996-2000 B.S., Department of Biochemistry, Shandong University
RESEARCH INTERESTS
One of the central questions in Neuroscience is how the brain learns, receives and stores information as memory. My laboratory is interested in elucidating the physiological mechanisms underlying learning and memory, and also pathogenic mechanisms underlying neurological disorders affecting learning and memory，such as Alzheimer’s Disease. To achieve this, we’re combining multidisciplinary tools to investigate the processes underlying learning and memory in molecular, cellular, circuit and animal levels. Specifically, we’re exploring 1) how lipid metabolism in the brain affects learning and memory in both physiological and pathological conditions; 2) whether the non-coding RNA network is involved in the regulation of learning and memory; 3) the relationship between brain energy homeostasis and learning and memory.
REPRESENTATIVE PUBLICATIONS
1. Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z2, Li J, Zhang J, Liu Q, SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE. Cell Rep. 2019 Jul 2;28(1):78-90.e6
2. Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L, Liu Q, Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation. Nat Commun. 2018 Apr 30;9(1):1726
3. Berg MG, Singh LN, Younis I, Liu Q,Pinto AM, Kaida D, Zhang Z, Cho S, SherrillMix S, Wan L, Dreyfuss G. U1 snRNPDetermines mRNA 2. Length and Regulates Isoform Expression. Cell.150: 53-64, 2012.
4. Liu Q, ZhangJ, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Lipoproteinreceptor LRP1 regulates leptin signaling and energy homeostasis in the adultcentral nervous system.PLoS Biology. 9(1):e1000575, 2011.
5. LiuQ,ZhangJ, TrotterJ, ChengC, HanX, WeeberEJ, BaoJ, HerzJ, Bu G. Lipoproteinreceptor LRP1 regulates age-dependent synaptic and neuronal degeneration bymodulating brain lipid metabolism. J. Neurosci. 30:17068-17078.2010.
6. Liu Q, Zhang J, Tran H, VerbeekMM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 andADAM17. Mol Neurodegener. 4:17, 2009.
7. Liu Q, Zerbinatti CV, Zhang J, Hoe HS, WangB, Cole SL, Herz J, Muglia L, Bu G. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1.Neuron.56:66-78,2007.
Website: http://en.hfnl.ustc.edu.cn/Faculty/Facultys/201410/t20141009_202979.html
E-mail: liuq2012@ustc.edu.cn
Phone: 0551-63601179