中国科学技术大学化学与材料科学学院梁高林课题组
梁高林 博士
中国科学技术大学化学与材料科学学院教授、博士生导师
教育部“新世纪优秀人才支持计划”入选者
2008-2010 美国斯坦福大学博士后
2010-至今 中国科学技术大学化学与材料科学学院教授、博士生导师
主要研究领域：
1)纳米分析化学：新型“click”反应的研究，用于体内外控制性合成发光纳米材料。包括超分子水凝胶，大分子纳米粒子,用于细胞显像和疾病诊断分析。
2)生物分析：细胞内各种蛋白水解酶的分析研究，细胞荧光、免疫荧光、电子电镜显像分析，动物肿瘤模型分析。
3)医学分析：各种显像剂的研究，显像分析技术包括光学，CT, SPECT, PET,MRI。研究新型的显像剂用于肿瘤的早期诊断分析及术后评价分析,以及新型抗肿瘤药物的研究。
1. Jiali Tan,* Mei Zhang, Zijuan Hai, Chengfan Wu, Jiong Lin, Wen Kuang, Hang Tang, Yulei Huang, Xiaodan Chen, and Gaolin Liang*. Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano 2019, 13(5), 5616-5622
2. Zijuan Hai, Yanhan Ni, Dilizhatai Saimi, Hongyi Yang, Haiyang Tong, Kai Zhong,* and Gaolin Liang*. γ-Glutamyltranspeptidase-Triggered Intracellular Gadolinium Nanoparticle Formation Enhances the T2-Weighted MR Contrast of Tumor. Nano Lett. 2019, 19(4), 2428-2433
3. Peiyao Chen,# Yinchu Ma,# Zhen Zheng,# Chengfan Wu, Yucai Wang,* and Gaolin Liang*. Facile syntheses of conjugated polymers for photothermal tumour therapy. Nat. Commun. 2019, 2019, 10, 1192
4. Chengfan Wu, Rui Zhang, Wei Du, Liang Cheng,* and Gaolin Liang*. Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for the Enhanced Photoacoustic Imaging of Tumors. Nano Lett. 2018, 18(12), 7749-7754
5. Wei Tang, Zhibin Zhao, Yuanyuan Chong, Chengfan Wu, Qingzhi Liu, Jingbo Yang, Rongbin Zhou, Zhe-Xiong Lian,* and Gaolin Liang*. Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect. ACS Nano 2018, 12(10), 9966-9973
6. Jindao Wu,* Zhen Zheng, Yuanyuan Chong, Xiangcheng Li, Liyong Pu, Qiyun Tang, Liu Yang, Xuehao Wang,* Fuqiang Wang,*, and Gaolin Liang*. Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection. Adv. Mater. 2018, 30(45), 1805018
7. Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng*, Wei Jiang*, and Rongbin Zhou*. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat. Commun. 2018, 9, 2550
8. Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang,* and Rongbin Zhou*. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol. Med. 2018, 10: e8689