高峰 博士
教育经历:
2008-2013 中国科学技术大学博士
2013-2015 苏州大学博士后
工作经历:
2015-至今 中国科学技术大学 特任副研究员
研究领域:
细胞和分子生物学
神经退行性疾病早期诊断生物标志物鉴定
毕丹蕾 博士
教育经历:
2009-2014 英国爱丁堡大学 博士
2014-2017 中国科学技术大学 博士后
工作经历:
2017-至今 中国科学技术大学 特任副研究员
论文发表:
1. Danlei Bi; Lang Wen; Zujun Wu; Yong Shen *; GABAergic dysfunction in excitatory and inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer’s disease, Alzheimer's & Dementia, 2020, 16(9): 1312-1329.
2. Peter Duncun #; Danlei Bi #; Heather McClafferty #; Lie Chen; Lijun Tian; Michael J. Shipston *; S-Acylation controls functional coupling of BK channel pore-forming α-subunits and β1-subunits., Journal of Biological Chemistry, 2019, 294(32): 12066-12076.
3. Shan Zhong; Mengdi Wang; Yaxi Zhan; Jie Zhang; Xiaoli Yang; Shumei Fu;Danlei Bi; Feng Gao; Yong Shen*; Zuolong Chen*; Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer's disease, Bioscience Biotechnology and Biochemistry, 2020, 84(5): 919-926.
4. Lie Chen; Danlei Bi; Zen Huat Lu; Heather McClafferty; Michael J. Shipston *; Distinct domains of the β1-subunit cytosolic N terminus control surface expression and functional properties of large-conductance calcium-activated potassium (BK) channels., The Journal of Biological Chemistry, 2017, 292(21): 8694-8704.
5. Lie Chen; Danlei Bi; Lijun Tian; Heather McClafferty; Franziska Steeb; Peter Ruth; Hans Guenther Knaus; Michael J Shipston *; Palmitoylation of the beta4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants., The Journal of Biological Chemistry, 2013, 288(18): 13136-13144.
6. Owen Jeffries; Nina Geiger; Iain C M Rowe; Lijun Tian; Heather McClafferty; Lie Chen; Danlei Bi; Hans Guenther Knaus; Peter Ruth; Michael J Shipston *; Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels., The Journal of Biological Chemistry, 2010, 285(43): 33307-33314.研究领域:
阿尔茨海默病脑内神经元过度兴奋机制研究